ICWA specifically states that if Native American children must be removed from their parent’s care, they must be placed with a Native-American household so as to preserve their culture.
After three years of college, Odenkirk decided to try writing and improv in Chicago.
First studying with Del Close, Odenkirk attended "The Players Workshop of the Second City" where he met Robert Smigel, and they began a collaboration that would last for years and take Odenkirk to Saturday Night Live.
From the late 1980s to 1990s, Odenkirk worked as a writer for television shows Saturday Night Live, Late Night with Conan O'Brien, Get a Life, The Ben Stiller Show and The Dennis Miller Show.
In the early 2000s, Odenkirk discovered the comedy duo Tim & Eric and produced their television series Tom Goes to the Mayor and Tim and Eric Awesome Show, Great Job!
He worked at WIDB where he created a late-night (midnight to 4am) radio comedy show called The Prime Time Special.
The show was considered hilarious and provided Bob an outlet for some of his natural talents.
He visited Chicago's Second City Theater at the age of fourteen.
His younger brother is comedy writer Bill Odenkirk.
He also performed at the Improv Olympic alongside notable comedians Chris Farley and Tim Meadows.
Odenkirk said his strongest comedic influence was Monty Python's Flying Circus, primarily due to its combination of cerebral and simple humor.
During his final summer hiatus, he wrote and acted in the Second City Mainstage show, Flag Burning Permitted in Lobby Only.